A unipolar cascade laser operating at 8.4 μm wavelength is reported. The structure, grown by molecular beam epitaxy in the AlInAs/GaInAs material system, contains a 25‐stage coupled‐quantum‐well active region. The waveguide design is optimized to enhance optical confinement and reduce losses associated with the interface plasmon mode, by taking advantage of the dispersion of the refractive index of the contact layer near the plasma frequency. The peak optical power is 30 mW and the threshold current density 2.8 kA/cm2, at a heat‐sink temperature of 100 K and the highest operating temperature is 130 K. The slope efficiency at 100 K is ∼0.1 W/A, corresponding to a differential quantum efficiency of 5.4% per stage. This work, combined with previous results on shorter wavelength quantum cascade lasers, demonstrates that the wavelength of these new light sources can be tailored over a wide range by changing the active layers’ thicknesses using the same materials.