Differences in Microsomal Enzyme Induction between Sprague-Dawley and Long-Evans Rats

Publisher Website
Google Scholar
Abstract
This study describes the effect of several inducing-agents on drug metabolism in Sprague-Dawley and Long-Evans rats. DDT, eucalyptol, and phenobarbital are less active in Long-Evans than in Sprague-Dawley rats. 3-Methylchol-anthrene, on the other hand, induces drug metabolism at similar extent in both strains. Experiments with phenobarbital show that the reduced reactivity of Long-Evans rats is dependent neither on the plasma and liver concentration of the inducing agent nor on time. However, a different reactivity to phenobarbital induction has been demonstrated in Long-Evans of 2 different sources.

This publication has 0 references indexed in Scilit: