Chemotherapeutic Studies on Cutaneous Leishmaniosis

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Abstract
The cutaneous infection of mouse obtained with a strain of L. brasiliensis causing in man the leproid form represents a suitable test for chemotherapeutic investigation. The infection has not been influenced by the antibiotics Fungizone and Fumagillin recently reported to possess antileishmanial action against L. donovani(10). A limited effect followed administration of pentavalent antimonials, consisting in a drop of the parasite number in the exudate and a temporary regression of the lesion, without indication for curative action. Thus, the drug sensitivity of the strain is totally different from the ones studied so far, which offers the possibility to reveal agents with a different strain specificity than the known ones.

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