6-(Substituted methylene)penems, potent broad spectrum inhibitors of bacterial .BETA.-lactamase. I. Racemic 6-ethylidenepenems.
- 1 January 1990
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 43 (1) , 70-75
- https://doi.org/10.7164/antibiotics.43.70
Abstract
The dehydration of various 6-(1-hydroxyethyl)penems to give E- and Z-6-ethyldidenepenems is described. Both isomers have been shown to be potent broad spectrum inhibitors of bacterial .beta.-lactamases capable of reducing the MIC values of .beta.-lactam antibiotics such as amoxycillin and cephaloridine against a wide range of resistant organisms.This publication has 1 reference indexed in Scilit:
- Asparenomycins A, B and C, new carbapenem antibiotics. V. Inhibition of .BETA.-lactamases.The Journal of Antibiotics, 1982