Syntheses of functionalised pyrido[2,3-b]indoles
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 2,p. 275-281
- https://doi.org/10.1039/p19920000275
Abstract
Two complementary routes for the synthesis of highly functionalised pyrido[2,3-b]indolesare described, starting from the readily available 2-amino-3-cyano-1-(4-methoxybenzyl)tetrahydroindole and methyl 2-aminoindole-3-carboxylate, respectively. The use of methyl 3-methoxycrotonate for pyridine-ring annelation, and the application of the 4-methoxybenzyl moiety as a protecting group for the indole nitrogen, are key features in these high yielding routes. Further transformations of the derived pyrido[2,3-b]indoles are presented.Keywords
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