Detecting functional modules in the yeast protein–protein interaction network
Open Access
- 12 July 2006
- journal article
- Published by Oxford University Press (OUP) in Bioinformatics
- Vol. 22 (18) , 2283-2290
- https://doi.org/10.1093/bioinformatics/btl370
Abstract
Motivation: Identification of functional modules in protein interaction networks is a first step in understanding the organization and dynamics of cell functions. To ensure that the identified modules are biologically meaningful, network-partitioning algorithms should take into account not only topological features but also functional relationships, and identified modules should be rigorously validated.Keywords
This publication has 32 references indexed in Scilit:
- Dissociation of the Nuf2-Ndc80 Complex Releases Centromeres from the Spindle-Pole Body during Meiotic Prophase in Fission YeastMolecular Biology of the Cell, 2005
- The Stanford Microarray Database accommodates additional microarray platforms and data formatsNucleic Acids Research, 2004
- Local graph alignment and motif search in biological networksProceedings of the National Academy of Sciences, 2004
- Protein interaction networks from yeast to humanCurrent Opinion in Structural Biology, 2004
- The architecture of complex weighted networksProceedings of the National Academy of Sciences, 2004
- Network biology: understanding the cell's functional organizationNature Reviews Genetics, 2004
- Gaining confidence in high-throughput protein interaction networksNature Biotechnology, 2003
- The ATP‐dependent helicase RUVBL1/TIP49a associates with tubulin during mitosisCell Motility, 2003
- Functional profiling of the Saccharomyces cerevisiae genomeNature, 2002
- The Human Genome Project—An OverviewMedicinal Research Reviews, 2000