Rho-family GTPases: it's not only Rac and Rho (and I like it)
Top Cited Papers
- 15 March 2004
- journal article
- review article
- Published by The Company of Biologists in Journal of Cell Science
- Vol. 117 (8) , 1301-1312
- https://doi.org/10.1242/jcs.01118
Abstract
The Rho-family proteins make up a major branch of the Ras superfamily of small GTPases. To date, 22 human genes encoding at least 25 proteins have been described. The best known `classical' members are RhoA, Rac1 and Cdc42. Highly related isoforms of these three proteins have not been studied as intensively, in part because it has been assumed that they are functionally identical to their better-studied counterparts. This now appears not to be the case. Variations in C-terminal-signaled modifications and subcellular targeting cause otherwise highly biochemically related isoforms (e.g. RhoA, RhoB and RhoC) to exhibit surprisingly divergent biological activities. Whereas the classical Rho GTPases are regulated by GDP/GTP cycling, other Rho GTPases are also regulated by other mechanisms, particularly by transcriptional regulation. Newer members of the family possess additional sequence elements beyond the GTPase domain, which suggests they exhibit yet other mechanisms of regulation.Keywords
This publication has 113 references indexed in Scilit:
- Tumor-related Alternatively Spliced Rac1b Is Not Regulated by Rho-GDP Dissociation Inhibitors and Exhibits Selective Downstream SignalingJournal of Biological Chemistry, 2003
- Crucial Role of TCL/TC10βL, a Subfamily of Rho GTPase, in Adipocyte DifferentiationJournal of Biological Chemistry, 2003
- RhoG Signals in Parallel with Rac1 and Cdc42Journal of Biological Chemistry, 2002
- The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreadingThe Journal of cell biology, 2002
- The Guanine Nucleotide-Binding Switch in Three DimensionsScience, 2001
- RhoB Is Dispensable for Mouse Development, but It Modifies Susceptibility to Tumor Formation as Well as Cell Adhesion and Growth Factor Signaling in Transformed CellsMolecular and Cellular Biology, 2001
- Rnd1, a Novel Rho Family GTPase, Induces the Formation of Neuritic Processes in PC12 CellsBiochemical and Biophysical Research Communications, 2000
- RhoA Prenylation Is Required for Promotion of Cell Growth and Transformation and Cytoskeleton Organization but Not for Induction of Serum Response Element TranscriptionJournal of Biological Chemistry, 2000
- Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growthOncogene, 1999
- Binding of prenylated and polybasic peptides to membranes: affinities and intervesicle exchangeBiochemistry, 1995