ACTIVITY AND POLYMORPHISM OF COBALT-ACTIVATED ACYLASE IN TISSUES OF RODENTS DURING DEVELOPMENT

  • 1 January 1978
    • journal article
    • research article
    • Vol. 25  (1) , 15-21
Abstract
The activity of Co-activated acylase, measured towards N-chloroacetyl- and N-butyryl-.gamma.-L-glutamyl-.beta.-naphthylamide, was found in all tissues of the adult animals. In the kidney, liver and small intestine of adult guinea-pig and rat 2 fractions differing in electrophoretic mobility (fractions 1 and 2) were present. The early fetus contained fraction 2, sometimes accompanied by fraction 3 which later disappeared; on further development of the fetus, fraction 1 appeared. Fraction 1 was distinctly activated by Co ions; fractions 2 and 3 were strongly inhibited by deaminated leucylphenylalanine. In the guinea-pig, the MW of the 3 fractions ranged from 43,000-59,000.

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