The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing
- 1 February 1987
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 325 (6106) , 673-678
- https://doi.org/10.1038/325673a0
Abstract
A small set of distinctive short RNA molecules are found in the nuclei of all higher eukaryotic cells and yeast, in protein complexes known as 'small nuclear ribonucleoprotein particles', or snRNPs. Recent work has confirmed early suggestions that these particles form part of the machinery by which primary RNA transcripts are processed to their mature, functional form. In particular, snRNPs have been shown to be an integral part of the 'spliceosome', a multi-component complex involved in the removal of intron sequences from the coding regions of messenger RNA precursors.Keywords
This publication has 102 references indexed in Scilit:
- A compensatory base change in U1 snRNA suppresses a 5′ splice site mutationCell, 1986
- Schizosaccharomyces pombe and saccharomyces cerevisiae: A look at yeasts dividedCell, 1986
- A small nuclear ribonucleoprotein associates with the AAUAAA polyadenylation signal in vitroCell, 1986
- Cleavage of 5′ splice site and lariat formation are independent of 3′ splice site in yeast mRNA splicingNature, 1985
- Accurate cleavage and polyadenylation of exogenous RNA substrateCell, 1985
- Cryptic branch point activation allows accurate in vitro splicing of human β-globin intron mutantsCell, 1985
- A role for branchpoints in splicing in vivoNature, 1985
- Aspects of biochemical catalysisCell, 1984
- Yeast contains small nuclear RNAs encoded by single copy genesCell, 1983
- Base-pairing interactions between small nuclear RNAs and nuclear RNA precursors as revealed by psoralen cross-linking in vivoCell, 1981