Clearing the Skies over Modular Polyketide Synthases
- 1 September 2006
- journal article
- Published by American Chemical Society (ACS) in ACS Chemical Biology
- Vol. 1 (8) , 505-509
- https://doi.org/10.1021/cb600376r
Abstract
Modular polyketide synthases (PKSs) are large multifunctional proteins that synthesize complex polyketide metabolites in microbial cells. A series of recent studies confirm the close protein structural relationship between catalytic domains in the type I mammalian fatty acid synthase (FAS) and the basic synthase unit of the modular PKS. They also establish a remarkable similarity in the overall organization of the type I FAS and the PKS module. This information provides important new conclusions about catalytic domain architecture, function, and molecular recognition that are essential for future efforts to engineer useful polyketide metabolites with valuable biological activities.Keywords
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