Polycythemia associated with a hemoglobinopathy.
Open Access
- 1 June 1966
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 45 (6) , 813-822
- https://doi.org/10.1172/jci105397
Abstract
An abnormal hemoglobin, called Chesapeake, was associated with mild polycythemia in a Caucasian family. Blood from heterozygous carriers had an O2 affinity as great as that of umbilical cord blood. An increased O2 affinity was a property of purified hemoglobin Chesapeake. Hemoglobin Chesapeake differed from hemoglobin-A in substitution of leucine for arginine in the 92 amino-acid residue of the [alpha]-chain. Hypotheses are presented relating the altered function of hemoglobin Chesapeake to this discrete structural abnormality.This publication has 24 references indexed in Scilit:
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