PERIPHERAL BLOOD B LYMPHOCYTES IN INFANCY AND CHILDHOOD

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Abstract
Ugazio, A. G., Marcioni, A. F., Astaldi, A. Jr and Burgio, G. R. (Paediatric Clinic, University Medical School of Pavia, Italy). Peripheral blood B lymphocytes in infancy and childhood. Acta Paediat Scand, 63: 205, 1974.–In order to investigate B lymphocytes in the paediatric age, 63 normal children were examined for the presence of immunoglobulin‐bearing lymphocytes in their peripheral blood. Lymphocytes were stained with a fluorescein‐conjugated anti‐immunoglobulin anti‐serum and the percentage of positive cells counted under ultraviolet light. The percentage of lymphocytes staining with fluorescein‐conjugated anti‐immunoglobulin antiserum has been shown to remain constant from the first days of life to adult age. It was concluded that an homeostatic mechanism maintains B cells a constant proportion of blood lymphocytes irrespective of the well known age‐dependent changes in the numbers of blood lymphocytes per volume whole blood.