Effects of Antiserum in Bloassay of Thyrotropin and Thyroid Activator of Hyperthyroidism

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Abstract
Summary Rabbit antisera to commercial and U.S.P. standard thyrotropin preparations were shown to inhibit biological assay of bovine pituitary thyrotropin. While similar inhibition of endogenous thyrotropin in serum from patients with myxedema was shown, the antisera did not inhibit the thyroid activator in blood of patients with Graves' disease. This constitutes further evidence for the dissimilarity of the thyroid activator of hyperthyroidism and thyrotropin.