Biogenesis of inner membrane proteins in Escherichia coli
Open Access
- 1 April 2001
- journal article
- review article
- Published by Wiley in Molecular Microbiology
- Vol. 40 (2) , 314-322
- https://doi.org/10.1046/j.1365-2958.2001.02392.x
Abstract
For a long time, it was generally assumed that the biogenesis of inner membrane proteins in Escherichia coli occurs spontaneously, and that only the translocation of large periplasmic domains requires the aid of a protein machinery, the Sec translocon. However, evidence obtained in recent years indicates that most, if not all, inner membrane proteins require the assistance of protein factors to reach their native conformation in the membrane. Here, we review and discuss recent advances in our understanding of the biogenesis of inner membrane proteins in E. coli.Keywords
This publication has 68 references indexed in Scilit:
- The Thylakoid ΔpH-dependent Pathway Machinery Facilitates RR-independent N-Tail Protein IntegrationJournal of Biological Chemistry, 2000
- Nascent Lep inserts into the Escherichia coli inner membrane in the vicinity of YidC, SecY and SecAFEBS Letters, 2000
- Crystal Structure of the Ribonucleoprotein Core of the Signal Recognition ParticleScience, 2000
- Role of Sec61α in the Regulated Transfer of the Ribosome–Nascent Chain Complex from the Signal Recognition Particle to the Translocation ChannelCell, 2000
- The positive inside rule is not determined by the polarity of the ΔψMolecular Microbiology, 1998
- The Aqueous Pore through the Translocon Has a Diameter of 40–60 Å during Cotranslational Protein Translocation at the ER MembraneCell, 1997
- Chaperonin-promoted Post-translational Membrane Insertion of a Multispanning Membrane Protein Lactose PermeaseJournal of Biological Chemistry, 1996
- The Cotranslational Integration of Membrane Proteins into the Phospholipid Bilayer Is a Multistep ProcessCell, 1996
- Sec-independent protein insertion into the innerE. colimembrane A phenomenon in search of an explanationFEBS Letters, 1994
- Control of topology and mode of assembly of a polytopic membrane protein by positively charged residuesNature, 1989