STUDIES ON HUMAN ADRENAL STEROIDS: 2. ISOLATION OF 20α-DIHYDROCORTICOSTERONE FROM THE PLASMA OF NORMAL MALES TREATED WITH CORTICOSTERONE

Abstract
Five fasting normal male humans were infused intravenously with 200 mg. of corticosterone. Blood samples were then withdrawn at various time intervals and the plasma was analyzed for individual [DELTA] 4-3-keto C21 adrenal steroids. In each case 20[alpha]-dihydrocorticosterone appeared as a metabolite. The isolated corticosterone and 20[alpha]-dihydrocorticosterone were characterized chemically and quantitative plasma levels of each are reported.