Chromosomal localization of the gene for AA-type platelet-derived growth factor receptor (PDGFRA) in humans and mice

1 January 1991

journal article
Published by S. Karger AG in Cytogenetic and Genome Research

Vol. 56 (3-4) , 160-163
https://doi.org/10.1159/000133076

Abstract

The full-length cDNA of the receptor for human AA-type platelet-derived growth factor (PDGF) was used to assign the PDGFRA gene to region q11→q21 of human chromosome 4 and to mouse Chromosome 5 by somatic cell hybrid analysis. Since the same region also contains the c-kit oncogene homolog KIT, we carried out pulsed-field gel electrophoresis to determine the physical distance between the two genes in human DNA. The two probes, when successively applied to the same filters, hybridized to a 450-kb EagI-fragment but not to other common restriction fragments. The genes are separated by at least one Notl, one Xhol, and one Sail site.

Keywords

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