REACTION OF MIXED CARBOXYLIC ANHYDRIDES WITH GRIGNARD REAGENTS. A USEFUL METHOD FOR THE PREPARATION OF KETONES
- 5 July 1974
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 3 (7) , 663-666
- https://doi.org/10.1246/cl.1974.663
Abstract
It was found that common ketones were prepared in good yields by the reaction of grignard reagents with mixed carboxylic anhydrides composed of o-substituted benzoic acids or pivalic acid and common carboxylic acids at −20 or −78°C. Further, it was established that a 1,4-diketone such as 2,5-dioxoundecane, a precursor of dihydrojasmone was synthesized in 71∼82% yields from levulinic acid by one step procedure without protecting its carbonyl group.Keywords
This publication has 3 references indexed in Scilit:
- Reaction of S-(2-pyridyl) thioates with Grignard reagents. Convenient method for the preparation of ketonesJournal of the American Chemical Society, 1973
- Mixed Carboxylic Anhydrides in the Grignard Reaction. I. Synthesis of Aldehydes from Formic Acetic Anhydride1The Journal of Organic Chemistry, 1964
- A STUDY OF REACTIONS OF GRIGNARD REAGENTS AT LOW TEMPERATURES1The Journal of Organic Chemistry, 1948