Mannose Receptor-Mediated Regulation of Serum Glycoprotein Homeostasis

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8 March 2002

journal article
other
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 295 (5561) , 1898-1901
https://doi.org/10.1126/science.1069540

Abstract

Carbohydrates are thought to function as tags that mark circulatory glycoproteins for rapid clearance. To examine the role of the mannose receptor (MR) in glycoprotein clearance, we generated mice genetically deficient in MR. MR^−/− mice were defective in clearing proteins bearing accessible mannose andN-acetylglucosamine residues and had elevated levels of eight different lysosomal hydrolases. Proteomic analysis of MR^−/− and control mouse sera showed that an additional 4 out of 52 proteins identified were elevated in MR^−/−serum. Each of these is up-regulated during inflammation and wound healing. Thus, MR appears to operate as an essential regulator of serum glycoprotein homeostasis.

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This publication has 23 references indexed in Scilit:

The Cysteine-Rich Domain of the Macrophage Mannose Receptor Is a Multispecific Lectin That Recognizes Chondroitin Sulfates a and B and Sulfated Oligosaccharides of Blood Group Lewisa and Lewisx Types in Addition to the Sulfated N-Glycans of Lutropin
The Journal of Experimental Medicine, 2000
A nonlinear wide‐range immobilized pH gradient for two‐dimensional electrophoresis and its definition in a relevant pH scale
Electrophoresis, 1993
Fetuin ‐ an old friend revisited
BioEssays, 1992
Circulatory half-life but not interaction with the lutropin/chorionic gonadotropin receptor is modulated by sulfation of bovine lutropin oligosaccharides.
Proceedings of the National Academy of Sciences, 1992
A hepatic reticuloendothelial cell receptor specific for SO4-4GalNAcβ1, 4GlcNAcβ1,2Manα that mediates rapid clearance of lutropin
Cell, 1991
Aminoterminal Propeptide of Type III Procollagen in Healing Wound in Humans
Annals of Surgery, 1987
Interferon α/β selectively antagonises down-regulation of mannosyl-fucosyl receptors on activated macrophages by interferon γ
Biochemical and Biophysical Research Communications, 1986
Recognition of lysosomal glycosidases in vivo inhibited by modified glycoproteins
Nature, 1976
2-Imino-2-methoxyethyl 1-thioglycosides: new reagents for attaching sugars to proteins
Biochemistry, 1976
The Role of Surface Carbohydrates in the Hepatic Recognition and Transport of Circulating Glycoproteins
Published by Wiley ,1974