Variation in Virulence of Coxsackie Virus B3 in the Heart of Mice

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Abstract
Histopathological analysis of the heart in adult mice inoculated with coxsackievirus B3 (CB3) strains revealed that strain SK-74 isolated from a patient suffering from severe diarrhea- and fever-produced severe myocarditis; strain T-70 isolated from a healthy child induced no lesion in the hearts of mice tested; intensities of myocardial lesions in mice inoculated with strain PMH were higher than those in mice inoculated with prototype strain Nancy. Thus, strain SK-74 is virulent, but strain T-70 is avirulent in mice. Apparently, the virulence of prototype strain Nancy in the heart of mice is enhanced by passages of the strain in the heart of mice. All 4 strains of CB3 produced lesions in the pancreas; lesions induced by strain T-70 were less severe than those induced by the other 3 strains.

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