Radiolabelled Pyrimidine Nucleosides to Monitor the Expression of HSV-1 Thymidine Kinase in Gene Therapy
- 1 April 1999
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 18 (4-5) , 1065-1066
- https://doi.org/10.1080/15257779908041646
Abstract
Selective radiolabelling and imaging of transduced HSV tk expressing cells was studied using [123I]IVFRU, [125I]FIRU and [125I]FIAU. Although all three radionucleosides accumulated in the KBALB-STK transduced murine tumour line in vitro and in vivo, [125I]FIRU provided optimal performance in terms of selectivity for HSV tk expressing cells and % of injected dose accumulating in the tumor.Keywords
This publication has 1 reference indexed in Scilit:
- Non-invasive scintigraphic monitoring of gene expression in a HSV-1 thymidine kinase gene therapy modelNuclear Medicine Communications, 1997