Renal Excretion of Uric Acid

Abstract
Sixteen, randomly-selected, physically fit, young men, undergoing a vigorous, four-month, underwater demolition-team training program, showed marked alterations in their serum uric acid concentrations that could not be accounted for by simultaneous alterations in their urinary indices of either uric acid production or excretion. Significant elevations in subjects' serum uric acid levels corresponded to periods of mental alertness and preparedness on their parts to meet with new challenges in training. The elevations seen in subjects' serum uric acid concentrations at these times may have been due to changes in their blood or plasma volume, secondary to a release of adrenal catecholamines.

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