Relationship of Virulence Factor Expression to Evolved Virulence in Mouse-Passaged Cryptococcus neoformans Lines
Open Access
- 1 October 2005
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 73 (10) , 7047-7050
- https://doi.org/10.1128/iai.73.10.7047-7050.2005
Abstract
Serial passage of Cryptococcus neoformans in mice increases virulence relative to the nonpassaged line. Postpassaged lines showed no difference in the expression of most known virulence factors, with the exception that the more virulent lines had smaller capsules in vitro. These data imply that other mechanisms of virulence remain to be discovered.Keywords
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