Some pharmacological actions of 2,5-dimethoxy-4-ethylamphetamine (DOET) in rats and mice
- 1 January 1975
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 27 (1) , 18-22
- https://doi.org/10.1111/j.2042-7158.1975.tb09372.x
Abstract
DOET, like DOM, exhibited pressor action in rats. This increase of blood pressure was blocked by pretreatment with cinanserin. DOET at high doses decreased the spontaneous locomotor activity of mice at the first hour but increased the activity at the second hour; a low dose was less effective. DOET also increased the rectal temperature of rats and this hyperthermic action was suppressed by pretreating the animals with cinanserin or methysergide. These actions of DOET were compared with those of DOM.Keywords
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