Hematologic Effect of cis-Platinum-Bleomycin Therapy

Publisher Website
Google Scholar
Abstract
A prospective study of the hematologic findings in 19 patients receiving cis-platinum (C-P) bleomycin (B) for squamous cell carcinoma of the head and neck was performed. CP 3 mg/kg was given on day 1, B 15 mg/m2 on day 3 and then by continous infusion from day 3 to 10. Hematocrits declined in all patients from a mean of 41.6 ± 3.9 to 36.6 ± 4.9 (p < 0.001) with the nadir seen by 10 days, reticulocyte count was unchanged. In 1 patient marked hemolysis occurred over 10-day period associated with the appearance of irregular spherocytes on smear, a situation similar to the index case which initiated this study. 5 other patients had spherocytes. A significant lymphopenia in the absence of neutropenia and thrombocytopenia was also observed.

This publication has 1 reference indexed in Scilit: