Absence of an Antigenic Component of Complement in NZB Mice
Open Access
- 1 March 1965
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 94 (3) , 437-442
- https://doi.org/10.4049/jimmunol.94.3.437
Abstract
Summary: Mice of the NZB strain, which develop spontaneous autoimmune disease, have been found to lack the complement antigen Hc1 and functional complement. They readily form antibodies to this antigen when immunized with sera from normal strains of mice. The other NZ mouse strains tested, NZW, NZY and NZCW, possess the Hc1 antigen, as do hybrids of NZB with C3H and NZW. The presence of complement may be associated with the florid kidney lesions described for NZB/NZW hybrids.Keywords
This publication has 1 reference indexed in Scilit:
- The Natural History of Autoimmune Disease in NZB MiceAnnals of Internal Medicine, 1963