Crystal and molecular structures of the inclusion compounds of cholic acid with methanol, ethanol and 1-propanol
- 1 June 1990
- journal article
- research article
- Published by International Union of Crystallography (IUCr) in Acta crystallographica Section B, Structural science, crystal engineering and materials
- Vol. 46 (3) , 399-405
- https://doi.org/10.1107/s0108768189014205
Abstract
The 1:1 inclusion compounds of cholic acid with methanol (C24H40O5.CH4O), ethanol (C24H40O5.C2H6O) and 1-propanol (C24H40O5.C3H8O) crystallize in the P2(1)2(1)2(1) space group with unit-cell dimensions at 293 K: a = 15.198 (6), b = 11.625 (7), c = 14.560 (9) A; a = 14.653 (7), b = 11.739 (4), c = 15.045 (2) A; and a = 15.026 (2), b = 11.864 (9), c = 14.951 (4) A; Z = 4. The structures were solved using direct methods. Full-matrix least-squares refinement reduced the conventional R factor to values of 0.109, 0.066 and 0.071, respectively. The alcohol molecules are contained in cavities created by the cholic acid molecules and are involved in the hydrogen-bonding scheme consisting of five unique hydrogen bonds. Statistical disorder is observed for the ethanol and 1-propanol molecules.Keywords
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