Nucleotide sequences of Immunoglobulin μ heavy chain deletion mutants
Open Access
- 1 January 1983
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 11 (21) , 7471-7485
- https://doi.org/10.1093/nar/11.21.7471
Abstract
Mutants of an IgM producing hybridoma cell line were isolated which produce n heavy chain fragments. Two such mutants were found to have internal deletions in the p gene and the nucleotide sequence of the deletion endpoints was determined. No evidence was found for a role of the heavy chain switch region in the formation of these deletions. The implications of these mutants in defining the requirements of immunoglobulin gene expression are discussed.Keywords
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