Bone Marrow T Cells

Open Access
Publisher Website
Google Scholar
Abstract
Mouse bone marrow (BM) contains cells capable of responding in vitro to the T cell mitogens, phytohemagglutinin (PHA) and concanavalin A (Con A). These responses are less vigorous than those of spleen cells. The optimal mitogen concentrations for BM cells are different from those for spleen cells; BM cells require twice as much PHA and Con A. In terms of the relative responses to these mitogens, the mean PHA/Con A ratio for adult BM is reversed as compared with spleen; in spleen it is 0.42 whereas in BM it is 1.3. This dichotomy is even clearer in newborn (6- to 8-day-old) mice. Newborn spleen cells respond poorly to PHA and relatively well to Con A. On the contrary, newborn BM cells respond almost as well to PHA as do adult BM cells but they do not respond to Con A. These findings suggest a significant difference between BM cells and spleen cells which respond to T cell mitogens.

This publication has 0 references indexed in Scilit: