In Vitro Activity of OPT-80 against Clostridium difficile
Open Access
- 1 June 2004
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 48 (6) , 2280-2282
- https://doi.org/10.1128/aac.48.6.2280-2282.2004
Abstract
Clostridium difficile remains the major cause of nosocomial diarrhea. Reports on impaired susceptibility of C. difficile to metronidazole and vancomycin and frequent relapses of patients after therapy necessitate the search for new substances. With this study, the activity of OPT-80, a new macrocycle, against 207 C. difficile strains and against other obligately anaerobic bacteria was tested. OPT-80 showed high in vitro activity against all C. difficile strains tested.Keywords
This publication has 10 references indexed in Scilit:
- Reassessment of Clostridium difficile Susceptibility to Metronidazole and VancomycinAntimicrobial Agents and Chemotherapy, 2002
- Health Care Costs and Mortality Associated with Nosocomial Diarrhea Due to Clostridium difficileClinical Infectious Diseases, 2002
- Reduced susceptibility ofClostridium difficileto metronidazoleJournal of Antimicrobial Chemotherapy, 2001
- Susceptibility testing of Clostridium difficile against metronidazole and vancomycin by disk diffusion and EtestDiagnostic Microbiology and Infectious Disease, 1999
- Recurrent Clostridium Difficile Disease: Epidemiology and Clinical CharacteristicsInfection Control & Hospital Epidemiology, 1999
- Antimicrobial Susceptibilities of Equine Isolates ofClostridium difficileand Molecular Characterization of Metronidazole‐Resistant Strains.Clinical Infectious Diseases, 1997
- Recurrent Clostridium difficile Diarrhea: Characteristics of and Risk Factors for Patients Enrolled in a Prospective, Randomized, Double-Blinded TrialClinical Infectious Diseases, 1997
- In vitro and in vivo evaluation of tiacumicins B and C against Clostridium difficileAntimicrobial Agents and Chemotherapy, 1991
- Tiacumicins, a novel complex of 18-membered macrolide antibiotics. I. Taxonomy, fermentation and antibacterial activity.The Journal of Antibiotics, 1987
- Lipiarmycin, a new antibiotic from Actinoplanes. III. Mechanism of action.The Journal of Antibiotics, 1975