Dose reduction of inhaled corticosteroids under concomitant medication with montelukast in patients with asthma

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Abstract
The present study aimed at comparing the effects of a dose reduction of inhaled corticosteroids on lung function, indirect measures of airway inflammation and clinical scores during treatment with a leucotriene receptor antagonist.In 50 patients (mean forced expiratory volume in one second (FEV1) 94% predicted), steroid doses (800 µg beclomethasone dipropionate) were first reduced to 50% and then to 25%, for 6 weeks each. One group received a placebo and the other group received montelukast (10 mg).The first reduction did not cause significant effects. During the second, FEV1and peak expiratory flow decreased in both groups (p1(PC20), sputum eosinophils and exhaled nitric oxide were mostly nonsignificant for both placebo and montelukast.These data demonstrate that a 75% reduction in the dose of steroid given to patients with asthma led to a deterioration in lung function not prevented by montelukast, whereas changes in clinical state seemed to favour montelukast treatment. It therefore appears that potential effects of montelukast, in the presence of low-dose steroids, could not be attributed to single indices of lung function or airway inflammation.