Analytic Review: The Pathogenetic and Prognostic Value of Biologic Markers in Acute Lung Injury
- 11 March 2009
- journal article
- review article
- Published by SAGE Publications in Journal of Intensive Care Medicine
- Vol. 24 (3) , 151-167
- https://doi.org/10.1177/0885066609332603
Abstract
Over the past 2 decades, measurement of biomarkers in both the airspaces and plasma early in the course of acute lung injury has provided new insights into the mechanisms of lung injury. In addition, biologic markers of cell-specific injury, acute inflammation, and altered coagulation correlate with mortality from acute lung injury in several single center studies as well as in multicenter clinical trials. To date, biomarkers have been measured largely for research purposes. However, with improved understanding of their role in the pathogenesis of acute lung injury, biomarkers may play an important role in early detection of lung injury, risk stratification for clinical trials, and, ultimately, tailoring specific therapies to individual patients. This article provides a review of biologic markers in acute lung injury, with an emphasis on recent analysis of results from multicenter clinical trials.Keywords
This publication has 122 references indexed in Scilit:
- Randomized Clinical Trial of Activated Protein C for the Treatment of Acute Lung InjuryAmerican Journal of Respiratory and Critical Care Medicine, 2008
- Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injuryIntensive Care Medicine, 2008
- Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injuryThorax, 2008
- Plasma Receptor for Advanced Glycation End-products Predicts Duration of ICU Stay and Mechanical Ventilation in Patients After Lung TransplantationThe Journal of Heart and Lung Transplantation, 2007
- Higher Urine Nitric Oxide Is Associated with Improved Outcomes in Patients with Acute Lung InjuryAmerican Journal of Respiratory and Critical Care Medicine, 2007
- Hyperoxia causes angiopoietin 2–mediated acute lung injury and necrotic cell deathNature Medicine, 2006
- Higher urine desmosine levels are associated with mortality in patients with acute lung injuryAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2006
- Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): paradox or paradigm?Thorax, 2006
- Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injuryAmerican Journal of Physiology-Lung Cellular and Molecular Physiology, 2005
- Adult Respiratory Distress Syndrome in Patients with Severe NeutropeniaNew England Journal of Medicine, 1986