A technique for stable adhesion of DNA to a modified graphite surface for imaging by scanning tunneling microscopy
- 1 March 1991
- journal article
- research article
- Published by American Vacuum Society in Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures
- Vol. 9 (2) , 1288-1290
- https://doi.org/10.1116/1.585223
Abstract
A procedure has been developed in which mercurated DNA is covalently bonded to a modified graphite surface. This technique allows for stable adhesion of the DNA which enables one to image it with the scanning tunneling microscope. The method is outlined in this paper and images are presented of a partially modified graphite surface and one completely modified with DNA attached. The DNA images demonstrate B-helix periodicity.Keywords
This publication has 2 references indexed in Scilit:
- Early melting of supercoiled DNANucleic Acids Research, 1988
- A two-state conformational equilibrium for alternating (A-T)n sequences in negatively supercoiled DNAJournal of Molecular Biology, 1987