Loss of transcription factor AP‐1 DNA binding activity during lymphocyte aging in vivo

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Abstract
The main feature of cellular senescence is cessation of cell proliferation. Protooncogene c‐fos, which is required for the cell to enter into DNA synthesis, is repressed in senescent fibroblasts. Diminished expression of c‐fos and impaired formation of AP‐1, which is a complex of c‐Fos and c‐Jun proteins acting as a transcription factor, was found in lymphocytes derived from old (> 18 months) mice and stimulated with Con A. There were no differences in c‐jun expression and formation of other transcription factors (AP‐2 and AP‐3) between lymphocytes isolated front old and young mice.