Synthesis of 2′,3′-Dideoxyinosine
- 1 April 1988
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 7 (2) , 147-153
- https://doi.org/10.1080/07328318808070199
Abstract
The synthesis of 2′,3′-dideoxyinosine (ddI, 1) from 2′-deoxyinosine and 2′,3′-dideoxyadenosine (ddA, 2) is described. Chemically, selective benzoylation of the 5′ hydroxyl group of 2′-deoxyinosine is followed by deoxy-genation at the 3′ position via the thioimidazolide 4. De-protection of the resulting 5′-O-benzoyl-2′,3′-dideoxyinosine 5 gave 2′,3′-dideoxyinosine 1. Enzymatically, deamination of ddA 2 with adenosine deaminase also yielded ddI.Keywords
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