MODE OF INTERACTION OF DIFFERENT POLYANIONS WITH FIRST (C1, C1BAR) 2ND(C2) AND 4TH(C4)COMPONENT OF COMPLEMENT

1 January 1976

journal article
research article

Vol. 31 (6) , 931-934

Abstract

Treatment of serum with dextran sulfate, polyvinylsulfate or polyanethol sulfonate resulted in a dose-dependent activation of C1 [the 1st complement component] and of C3; this was found for normal serum and for C4-deficient guinea pig serum. Activation of C1 and C3 occurred at the same concentration of polyanions . The consumption of C3 in C4 deficient serum and the requirement of factor D of the alternative pathway indicate that C3 is activated via the alternative pathway.

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