Reduction of Group Reactivity of Complement Fixing Antigen of Meningopneumonitis Virus by Potassium Periodate.
- 1 December 1953
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 84 (3) , 517-520
- https://doi.org/10.3181/00379727-84-20697
Abstract
The group reactivity of the meningopneumonitis complement fixing antigen was reduced by treatment with KIO4. Results were of 3 kinds, depending on the state of the original antigen. (1) The group reactivity of the crude antigen was left practically unaltered. (2) Most of this reactivity was removed by KIO4 from the purified antigen. Such prepns. became inactive or only slightly active in the CF test with either homologous or heterologous antisera, since the specific activity was previously destroyed by heating. (3) Antigens possessing the heat-labile specific component as well as the K3O4-susceptible group-reactive "component" could be rendered fairly specific by treatment with KIO4. It appears that the group reactive "component" is not a single entity, but is made up of at least 2 antigenic constituents.Keywords
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