Liquid chromatographic retention of β-adrenoceptor antagonists: an index of lipid solubility
- 1 June 1984
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 36 (6) , 400-401
- https://doi.org/10.1111/j.2042-7158.1984.tb04407.x
Abstract
The in-vitro lipophilicity of nine β-adrenoceptor antagonists was evaluated based on retention on a reverse-phase C−18 high-pressure liquid chromatographic (hplc) system at physiologic pH. Propranolol was by far the most lipophilic drug, while atenolol and sotolol were the least. Hplc retention was highly correlated (r = 0·92) with octanol: buffer partition coefficient. Thus hplc retention is a rapid and replicable approach to the determination of in-vitro lipophilicity that does not require radioactive drug.Keywords
Funding Information
- United States Public Health Service (MH-34223)
This publication has 9 references indexed in Scilit:
- IN VITRO QUANTITATION OF BENZODIAZEPINE LIPOPHILICITY: RELATION TO IN VIVO DISTRIBUTIONBritish Journal of Anaesthesia, 1983
- Correlations between liquid chromatographic capacity ratio data on lichrosorb RP-18 and partition coefficients in the octanol—water systemJournal of Chromatography A, 1982
- Liquid Chromatographic Determination of Chlordiazepoxide and Metabolites in PlasmaPharmacology, 1982
- Correlation of Reversed-Phase Capacity Factors for Barbiturates with Biological Activities, Partition Coefficients, and Molecular Connectivity IndicesJournal of Chromatographic Science, 1981
- Cerebrospinal fluid concentrations of propranolol, pindolol and atenolol in man: evidence for central actions of beta‐adrenoceptor antagonists.British Journal of Clinical Pharmacology, 1981
- Inhibition of oxidative drug metabolism by beta‐adrenoceptor antagonists in related to their lipid solubility [letter]British Journal of Clinical Pharmacology, 1981
- An investigation of the comparative liposolubilities of β-adrenoceptor blocking agentsJournal of Pharmacy and Pharmacology, 1981
- Is there a relationship between the physical properties and cardioselectivity of beta-adrenoceptor antagonists?Published by Wiley ,1981
- Partition coefficients and their usesChemical Reviews, 1971