STUDIES ON EFFECT OF TOBACCO-SMOKE ON BIOTRANSFORMATION OF VASOACTIVE SUBSTANCES IN ISOLATED PERFUSED RABBIT LUNG .1. PROSTAGLANDIN F-2-ALPHA

  • 1 January 1977
    • journal article
    • research article
    • Vol. 18  (3) , 495-506
Abstract
Cigarette smoke administration was previously found to have a pronounced inhibitory effect on metabolism of nicotine and benzo[a]pyrene in the isolated perfused rabbit lung. These observations suggest the possibility of tobacco smoke inhibition of biotransformation associated with non-ventilatory pulmonary functions such as metabolic clearance of endogenous vasocative substances. Studies of the effect of smoke on uptake and metabolism of PGF2.alpha. in isolated perfused rabbit lungs provide no evidence of inhibition of these processes.

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