What Are Surrogate Outcome Measures and Why Do They Fail in Clinical Research?
- 16 June 1999
- journal article
- review article
- Published by S. Karger AG in Neuroepidemiology
- Vol. 18 (4) , 167-173
- https://doi.org/10.1159/000026208
Abstract
Surrogate outcome measures have been of interest in clinical research for a long time because of their potential ability to save time and cost. The literature, however, has numerous examples of failed surrogate measures. The definition of a surrogate outcome measure, its consideration in clinical stroke research and some of the potential mechanisms for failure of surrogate measures will be discussed.Keywords
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