Primary hyperparathyroidism: evaluated by 47Calcium kinetics, calcium balance and serum bone‐Gla‐protein

Publisher Website
Google Scholar
Abstract
Combined 47Calcium kinetic and calcium balance studies with correction for dermal calcium loss were performed in thirteen patients with primary hyperparathyroidism (PHP), in whom serum bone-Gla-protein (S-BGP) was measured, and in ten matched controls. Dietary calcium was normal in PHP but both net (7.9 .+-. 1.4 mmol Ca day-1 in PHP v. 3.5 .+-. 0.9 mmol Ca day-1 in normals (mean .+-. SE)) and true (11.1 .+-. 1.6 v. 6.8 .+-. 0.9 mmol Ca day-1) intestinal absorbed calcium were enhanced (P < 0.05). The renal calcium excretion (10.9 .+-. 0.8 v. 5.1 .+-. 0.4 mmol Ca day-1, P < 0.001) and the dermal calcium loss (2.5 .+-. 0.3 v. 1.5 .+-. 0.1 mmol Ca day-1, P < 0.02) were increased in PHP. Both patients and controls were in a negative calcium balance (P < 0.01 and P < 0.001, respectively) without any difference between the groups (P > 0.10). Mineralization (12.0 .+-. 1.7 v. 4.8 .+-. 0.8 mmol Ca day-1, P < 0.02) and resorption rates (17.6 .+-. 2.5 v. 7.9 .+-. 0.6 mmol Ca day-1, P < 0.02) were increased in PHP and S-BGP correlated positively to both variables (r = 0.64, P < 0.05 and r = 0.62, P < 0.05, respectively). Serum immunoreactive parathyroid hormone correlated positively to serum calcium (r = 0.69, P < 0.01) but not to the calcium kinetic data.