HOST REPOPULATION OF ENDOTHELIUM IN HUMAN KIDNEY TRANSPLANTS

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Abstract
The sex chromatin body count in endothelial cells from transplanted human kidneys has been used in an attempt to study whether significant repopulation of the endothelium with host cells occurs. The counts from male kidneys transplanted into females were apparently higher than counts from male controls or male to male transplants but did not reach “normal female” levels, even after 2 years in situ. On the other hand, counts from female kidneys transplanted into males remained high, and in one case were in the normal female range over 3 years after transplantation. The difficulties in interpreting sex chromatin counts are discussed and it is concluded that host repopulation probably does not play any part in protecting human kidneys from rejection.

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