Varieties of Significance
- 25 October 1973
- journal article
- clinical trial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 289 (17) , 923-924
- https://doi.org/10.1056/nejm197310252891729
Abstract
To the Editor: Editors who add additional departments not only crowd the cover with that new department but also must expect in some instances a sharp expansion of the correspondence section. In his essay entitled "Administratively Significant" (N Engl J Med 289:155–157, 1973) Dr. Buncher tramples on an ethical principle that is the very backbone of successful clinical trials. A clinical investigator can justify asking a patient to be randomized into one of two treatment groups only if there is no reasonable consensus that one treatment is better than the other. Once a difference has reached statistical significance, the informed-consent . . .Keywords
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