Inhibition of Myeloperoxidase Release from Rat Polymorphonuclear Leukocytes by a Series of Azachalcone Derivatives
- 1 December 1994
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 37 (25) , 4357-4362
- https://doi.org/10.1021/jm00051a013
Abstract
A series of azachalcones was evaluated for ability to affect secretion of myeloperoxidase by rat polymorphonuclear leukocytes stimulated by fMLP. The compounds were found to interfere with cellular uptake of extracellular calcium. Structure-activity relationships are discussed.Keywords
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