Further Subgrouping of the Human Adenoviruses by Differential Hemagglutination
- 1 October 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 128 (4) , 541-550
- https://doi.org/10.1093/infdis/128.4.541
Abstract
A total of 590 cultures of adenovirus, including all 33 prototype strains and 346 wild strains, were studied for determination of their agglutinability with red blood cells (RBC) of 14 animal species. All variables normally encountered in HA tests, such as host culture system, harvest conditions, hemagglutinin stability, reproducibility of the HA test system, and erythrocyte sensitivity, were considered. Although most adenovirus serotypes showed distinctive composites of agglutinability with RBC from all species at 37 C, 22 C, and 2 C, the 33 types that infect man were divided into 10 subgroups solely on the basis of differential hemagglutination titers with rhesus monkey, human, and rat erythrocytes at 37 C. These subgroups were helpful in identification of adenovirus isolates, which were correctly subgrouped 94% of the time in a blind, coded evaluation, and in characterization of intermediate and atypical strains.Keywords
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