Proximal–distal axis formation in the Drosophila leg
- 10 July 1997
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 388 (6638) , 139-145
- https://doi.org/10.1038/40563
Abstract
Limb development requires the formation of a proximal–distal axis perpendicular to the main anterior–posterior and dorsal–ventral body axes. The secreted signalling proteins Decapentaplegic and Wingless act in a concentration-dependent manner to organize the proximal–distal axis. Discrete domains of proximal–distal gene expression are defined by different thresholds of Decapentaplegic and Wingless activities. Subsequent modulation of the relative sizes of these domains by growth of the leg is required to form the mature pattern.Keywords
This publication has 47 references indexed in Scilit:
- ORGANIZING SPATIAL PATTERN IN LIMB DEVELOPMENTAnnual Review of Cell and Developmental Biology, 1996
- Morphogens, Compartments, and Pattern: Lessons from Drosophila?Cell, 1996
- Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wingNature, 1996
- Direct and Long-Range Action of a DPP Morphogen GradientCell, 1996
- Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing drosophila wingCell, 1995
- fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing developmentCell, 1994
- Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog proteinNature, 1994
- Organization of wing formation and induction of a wing-patterning gene at the dorsal/ventral compartment boundaryNature, 1994
- Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discsCell, 1994
- Interaction between dorsal and ventral cells in the imaginal disc directs wing development in DrosophilaCell, 1993