Molecular mechanisms of tumor necrosis factor‐induced cytotoxicity
Open Access
- 28 February 1994
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 340 (1-2) , 9-16
- https://doi.org/10.1016/0014-5793(94)80163-0
Abstract
Although TNF plays an important role in several physiological and pathological conditions, the hallmark of this important cytokine has been its selective cytotoxic activity on tumor cells. Since its cloning in 1984, understanding of how TNF selectively kills tumor cells has been the subject of research in many laboratories. Here we review TNF‐induced post‐receptor signaling mechanisms which seem to be involved in the pathway to cytotoxicity.Keywords
This publication has 68 references indexed in Scilit:
- Tumor necrosis factor cytotoxicity is associated with phospholipase D activationEuropean Journal of Biochemistry, 1993
- The Pathophysiology of Tumor Necrosis FactorsAnnual Review of Immunology, 1992
- Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free SystemScience, 1992
- Tumor necrosis factor Characterization at the molecular, cellular and in vivo levelFEBS Letters, 1991
- Inhibition by glucocorticoids of tumor necrosis factor‐mediated cytotoxicityFEBS Letters, 1990
- Tumor necrosis factor-α induces the phosphorylation of 28kDa stress proteins in endothelial cells: Possible role in protection against cytotoxicity?Biochemical and Biophysical Research Communications, 1989
- Inhibition of target cell mitochondrial electron transfer by tumor necrosis factorFEBS Letters, 1989
- Modulation of tumor necrosis factor-α cytotoxicity in L929 cells by bacterial toxins, hydrocortisone and inhibitors of arachidonic acid metabolismBiochemical and Biophysical Research Communications, 1987
- Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolismBiochemical and Biophysical Research Communications, 1987
- Recombinant tumor necrosis factor: its effect and its synergism with interferon-γ on a variety of normal and transformed human cell linesEuropean Journal of Cancer and Clinical Oncology, 1986