N-substituted pyrrolidin-3-ones as heterocyclic building blocks. Enantioselective synthesis of 8-epi- and 1,8,8a-triepi-castanospermine
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 2,p. 166-168
- https://doi.org/10.1039/c39920000166
Abstract
Regioselective aldol reaction of dianion 1 with aldehyde 5 provides the basis of a new approach to the construction of polyhydroxy indolizidines and the application of this methodology to the synthesis of 8-epicastanospermine 11 and 1,8,8a-triepicastanospermine 12 is described.Keywords
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