ALTERATIONS IN RESPONSE TO SOMATIC PAIN ASSOCIATED WITH ANAESTHESIA

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Abstract
It has been shown that tibial pressure algesimetry can be used to distinguish between the action of intramuscular pethidine 100 mg and a placebo. This method has been applied to study the effect on pain response of the opiate antagonists, levallorphan, nalorphine and four different doses of pentazocine. The two former drugs increased the sensitivity to pain soon after administration, though this effect diminished towards the end of the first hour. Pentazocine, on the other hand, had a demonstrable analgesic action. The opiate antagonist tacrine did not appear to affect the analgesic action of morphine 10 mg. None of the antagonists when given intravenously had an analgesic action comparable to pethidine though there was a wide scatter in the results. Nalorphine and levallorphan partially neutralized the effect of pethidine given previously. Pentazocine had no such antagonistic effect. It appears, therefore, that it differs from the other opiate antagonists studied which are antanalgesic or neutral by all the methods of administration used.

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