In vitro Inhibition of Rat Intestinal Surface Hydrolysis of Disaccharides and Dipeptides by Guaran

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Abstract
The effect of guaran on intestinal surface hydrolases was studied in everted jejunal segments by measuring the hydrolysis of maltose and phenylalanylglycine. Based on kinetic experiments, guaran inhibited competitively the hydrolysis of the substrates only if the cleavage was performed with intact tissue. Hydrolysis in mucosal homogenates was not affected by guaran; this polysaccharide may increase the diffusion barrier overlaying the mucosa and may retard final digestion of carbohydrates and peptides. [Inhibition of carbohydrate digestion by guaran may serve as an adjunct therapy for diabetes and obesity.].

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