Clinical and Laboratory Studies of Live Cytomegalovirus Vaccine Ad-169

Publisher Website
Google Scholar
Abstract
Live strain Ad-169 vaccine was prepared in human diploid cell strain WI-38 and studied clinically in 43 adult male priests and seminarians. All seronegative persons who were vaccinated developed antibody [Ab] and the immune adherence and neutralizing Ab persisted at high levels for at least 1 yr. Clinical reactions were minor, consisting mainly of soreness, induration and erythema at the injection site and mild systemic reaction including headache, chills, fatigue, myalgia and fever in a few persons. It was not possible to recover virus from the peripheral leukocytes, urine or throat of seronegative persons who were vaccinated. Susceptible persons who were in contact with the vaccinated persons failed to excrete virus and to develop Ab, indicating lack of contagious spread of the vaccine virus. Continuing investigations to measure the safety and efficacy of the vaccine seem highly justified in view of the importance of the virus in fetal damage, transfusion disease and organ transplantation.